Mesothelioma is really a rare and aggressive form of cancer. Generally, the prognosis is very poor at the time of diagnosis. In general, patients have not more than 12 months to live following a positive mesothelioma diagnosis. Hence, the treatment options for such an aggressive and rapidly developing disease are very limited. Mesothelioma treatment is usually palliative. Quite simply, the objective of treatment is simply to relieve the patient from the pain linked to the mesothelioma. There isn't any hope of curing the individual in the disease for many reasons:
(i) Diagnosis occurs very late in the development of the disease. When diagnosis is created there isn't any expect the patient.
(ii) The introduction of the disease is very rapid and affects key organs such as the heart and also the lungs.
Surgery
Surgery or cytoreduction requires the elimination of all or nearly all visible tumor. In the event of mesothelioma, this really is generally coupled with chemotherapy to give a far more effective elimination of cancerous cells. Some surgical operations aim to cure the individual completely particularly if the cancer continues to be localized. In many other cases, surgery may have a palliative effect because the cancerous mass is reduced. The next kinds of surgical procedures are used in mesothelioma treatment:
(i) Pleurodesis: insertion of the irritant within the pleural space causing an inflammation; this closes down the pleural space thus preventing build-up of fluid (pleural effusion). Most symptoms associated with pleural mesothelioma can be abated with this particular method for some time. A thoracoscope is used for this.
(ii) Pleurectomy or peritonectomy: elimination of part of the chest lining or abdomen lining (depending on in which the cancer is).
(iii) Decortication: removal of all or area of the membrane covering an organ.
(iv) Pneumonectomy: elimination of the whole affected lung (in most cases, mesothelioma develops on only one lung so that elimination of that lung may cure the individual when the cancer hasn't spread).
Chemotherapy
Chemotherapy requires the administration of medication that destroy cancerous cells. Chemotherapy in the treatment of mesothelioma can have the following objectives:
(i) Shrinking of tumors just before surgery (neo-adjuvant chemotherapy).
(ii) Destruction of cancer cells after surgery (adjuvant chemotherapy).
(iii) Boost the effectiveness of radiotherapy (immunotherapy).
Chemotherapy can also be used in cases where the cancer cells have spread beyond the initial site of occurrence. It is also used where the patient is not a candidate for surgery.
The most used drug for mesothelioma is pemetrexed that is an inhibitor of numerous proteins that are required for DNA synthesis and cell replication.
Chemotherapy has various negative effects because in the process of destroying cancer cells healthy cells are also harmed.
Radiotherapy
This refers back to the treatment of cancer by using penetrating beams of high energy. In the case of mesothelioma, radiotherapy may be used in conjunction with surgery in an attempt to cure in order to control severity of symptoms. An example of radiotherapy is the Intensity Modulated Radiation Therapy (IMRT) which uses computer generated images to focus on cancer cells directly with limited effect on surrounding tissue.
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